IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy

被引:343
作者
Yue, Caixia [1 ]
Liu, Peng [1 ]
Zheng, Mingbin [1 ,2 ]
Zhao, Pengfei [1 ]
Wang, Yiqing [1 ]
Ma, Yifan [1 ]
Cai, Lintao [1 ]
机构
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China
[2] Guangdong Med Coll, Dept Chem, Dongguan 523808, Peoples R China
基金
中国国家自然科学基金;
关键词
Drug delivery; Heparin; Imaging analysis; Laser ablation; Nanoparticle; WALLED CARBON NANOTUBES; FOLATE RECEPTOR-ALPHA; SURFACE-CHEMISTRY; DRUG-DELIVERY; IN-VITRO; HEPARIN; CANCER; CONJUGATE; ANGIOGENESIS; DOXORUBICIN;
D O I
10.1016/j.biomaterials.2013.05.071
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
IR-780 iodide is a near-infrared (NIR) fluorescence dye with higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG). Meanwhile, IR-780 can be utilized in photothermal therapy with laser irradiation. IR-780 is an important theranostic agent but its lipophilicity limited its application. In this paper, we synthesize multifunctional heparin-folic acid-IR-780 nanoparticles (HF-IR-780 NPs) by self-assembly of the heparin folic acid conjugate and IR-780 through ultrasonic sound method. The HF-IR-780 NPs exhibit good monodispersity, significant stability, and excellent molecular targeting to folate receptor over-expressing MCF-7 cells. Furthermore, the in vivo biodistribution experiments show that the HF-IR-780 NPs are specifically targeted to the tumor and can be used for tumor imaging. The in vitro cell viability assays and in vivo photothermal therapy experiments indicate that MCF-7 cells or MCF-7 xenograft tumors could be ablated by combining HF-IR-780 NPs with irradiation of an 808 nm laser. The photothermal therapy in vivo with a single-dose treatment has not caused significant adverse effect. The resulted HF-IR-780 NPs are a potential theranostic agent for imaging-guided cancer therapy. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:6853 / 6861
页数:9
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