Artemisinins: their growing importance in medicine

被引：245
作者：
Krishna, Sanjeev [1 ]
Bustamante, Leyla [1 ]
Haynes, Richard K. [2 ]
Staines, Henry M. [1 ]
机构：
[1] Univ London, Ctr Infect, Div Cellular & Mol Med, London SW17 0RE, England
[2] Hong Kong Univ Sci & Technol, Inst Mol Technol Drug Discovery & Synth, Dept Chem, Open Lab Chem Biol, Kowloon, Hong Kong, Peoples R China
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2008年 / 29卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/j.tips.2008.07.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis. More recently, they have also shown potent and broad anticancer properties in cell lines and animal models. In this review, we discuss recent advances in defining the role of artemisinins in medicine, with particular focus on their controversial mechanisms of action. This safe and cheap drug class that saves lives at risk from malaria can also have important potential in oncology.
引用
收藏
页码：520 / 527
页数：8
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