Preparation of substituted piperazinones via tandem reductive amination-(N,N′-acyl transfer)-cyclization

被引：36
作者：
Beshore, DC [1 ]
Dinsmore, CJ [1 ]
机构：
[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 07期
关键词：
D O I：
10.1021/ol025644l
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A one-pot, tandem reductive amination-transamidation-cyclization reaction was employed to produce substituted piperazin-2-ones in good yields. Various amino acid methyl esters and transferable acyl groups were examined to establish the reaction's scope.
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页码：1201 / 1204
页数：4
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