Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation

被引：28

作者：

González-Villalva, A

Fortoul, TI ^{[1
]}

Avila-Costa, MR

Piñón-Zarate, G

Rodriguez-Lara, V

Martínez-Levy, G

Rojas-Lemus, M

Bizarro-Nevarez, P

Díaz-Bech, P

Mussali-Galante, P

Colin-Barenque, L

机构：

[1] Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, FES Iztacala, Mexico City 04510, DF, Mexico

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2006年 / 22卷 / 03期

关键词：

inhalation exposure; megaplatelets; metals; thrombocytosis; vanadium;

D O I：

10.1191/0748233706th250oa

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Reports about vanadium (V) inhalation toxicity on the hematopoietic system, specifically about coagulation are limited. Therefore, we decided to evaluate the effects of V with a complete blood count and morphologic analysis of platelets on blood smears. CD-1 male mice inhaled V2O5 0.02 M 1 h twice weekly over 12 weeks. Blood samples were obtained by direct heart puncture; Wright stained smears were used for platelet quantification. An increase in platelet count from the third week of exposure was observed, as well as the presence of megaplatelets. Our results demonstrate, for the first time, that V induces thrombocytosis and it might correlate with some thromboembolic diseases. Further analysis is needed to evaluate the functionality of these platelets as well as the cause of its increase.

引用

页码：113 / 116

页数：4

共 12 条

[1]

Avila-Costa M.R., 2004, NEUROCHEM RES, V7, P1357, DOI [10.1023/B: NERE.0000026398.86113.7d, DOI 10.1023/B:NERE.0000026398.86113.7D]

[2]

Beutler E., 2001, WILLIAMS HEMATOLOGY, V6

[3]

BRAUER M, 2001, ENVIRON HEALTH PERSP, V109, P139

[4] Air pollution and cardiovascular disease - A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association [J].

Brook, RD ;

Franklin, B ;

Cascio, W ;

Hong, YL ;

Howard, G ;

Lipsett, M ;

Luepker, R ;

Mittleman, M ;

Samet, J ;

Smith, SC ;

Tager, I .

CIRCULATION, 2004, 109 (21) :2655-2671

[5] Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines [J].

Clarke, RW ;

Coull, B ;

Reinisch, U ;

Catalano, P ;

Killingsworth, CR ;

Koutrakis, P ;

Kavouras, I ;

Murthy, GGK ;

Lawrence, J ;

Lovett, E ;

Wolfson, JM ;

Verrier, RL ;

Godleski, JJ .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 (12) :1179-1187

[6] ACUTE RESPIRATORY EFFECTS OF PARTICULATE AIR-POLLUTION [J].

DOCKERY, DW ;

POPE, CA .

ANNUAL REVIEW OF PUBLIC HEALTH, 1994, 15 :107-132

[7]

*ENV HLTH CRIT, 1998, 81 ENG HLTH CRIT

[8] Vanadium in ambient air:: Concentrations in lung tissue from autopsies of Mexico City residents in the 1960s and 1990s [J].

Fortoul, TI ;

Quan-Torres, A ;

Sánchez, I ;

López, IE ;

Bizarro, P ;

Mendoza, ML ;

Osorio, LS ;

Espejel-Maya, G ;

Avila-Casado, MD ;

Avila-Costa, MR ;

Colin-Barenque, L ;

Villanueva, DN ;

Olaiz-Fernandez, G .

ARCHIVES OF ENVIRONMENTAL HEALTH, 2002, 57 (05) :446-449

[9] Metals in lung tissue from autopsy cases in Mexico City residents: Comparison of cases from the 1950s and the 1980s [J].

Fortoul, TI ;

Osorio, LS ;

Tovar, AT ;

Salazar, D ;

Castilla, ME ;

OlaizFernandez, G .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1996, 104 (06) :630-632

[10] Ambient pollution and heart rate variability [J].

Gold, DR ;

Litonjua, A ;

Schwartz, J ;

Lovett, E ;

Larson, A ;

Nearing, B ;

Allen, G ;

Verrier, M ;

Cherry, R ;

Verrier, R .

CIRCULATION, 2000, 101 (11) :1267-1273

← 1 2 →