Metal-free NaI/TBHP-mediated sulfonylation of thiols with sulfonyl hydrazides

被引：62

作者：

Chen, Qian ^{[1
,2
]}

Huang, Yulin ^{[1
]}

Wang, Xiaofeng ^{[1
]}

Wu, Jiawei ^{[1
]}

Yu, Guodian ^{[1
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China

[2] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 10期

关键词：

BASE-CATALYZED OXIDATION; THIOSULFONATE S-ESTERS; PEPTIDE HYDRAZIDES; CHEMICAL-SYNTHESIS; ORGANIC DISULFIDES; C(SP(3))-H BOND; CHLORIDES; SULFENYLATION; ACIDS; SULFONYLHYDRAZIDES;

D O I：

10.1039/c8ob00244d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient sulfonylation of thiols has been achieved through the metal-free NaI/TBHP-mediated cross-coupling of sulfonyl hydrazides and thiols at room temperature. This method provides a convenient and practical route to thiosulfonates in 84-99% yields (39 examples) with wide functional group compatibility.

引用

页码：1713 / 1719

页数：7

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