Shared liver-like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors

被引：7

作者：

Cheng, Jun ^{[1
]}

Song, Xuekun ^{[2
]}

Ao, Lu ^{[1
]}

Chen, Rou ^{[1
]}

Chi, Meirong ^{[1
]}

Guo, You ^{[1
]}

Zhang, Jiahui ^{[1
]}

Li, Hongdong ^{[1
]}

Zhao, Wenyuan ^{[2
]}

Guo, Zheng ^{[1
,2
,3
]}

Wang, Xianlong ^{[1
]}

机构：

[1] Fujian Med Univ, Sch Basic Med Sci, Minist Educ Gastrointestinal Canc, Fujian Key Lab Med Bioinformat,Key Lab, Fuzhou 350122, Fujian, Peoples R China

[2] Harbin Med Univ, Dept Syst Biol, Coll Bioinformat Sci & Technol, Harbin 150086, Heilongjiang, Peoples R China

[3] Fujian Med Univ, Fujian Key Lab Tumor Microbiol, Fuzhou 350122, Fujian, Peoples R China

来源：

JOURNAL OF CANCER | 2018年 / 9卷 / 08期

关键词：

colorectal cancer; liver metastasis; microdissection; micro-environment; transcriptional characteristics; CANCER-PATIENTS; DATA SETS; EXPRESSION; SURVIVAL; PATHWAY; EXPLORATION; PROGRESSION; METABOLISM; PROGNOSIS; CARCINOMA;

D O I：

10.7150/jca.23017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma. Methods: Among the genes up-regulated in normal liver tissues versus normal colorectal tissues, we identified "liver-specific" genes whose expression levels ranked among the bottom 10% ("unexpressed") of all measured genes in both normal colorectal tissues and primary colorectal tumors without metastasis. These liver-specific genes were investigated for their expressions in both the primary tumors and the corresponding liver metastases of seven primary CRC patients with liver metastasis using microdissected samples. Results: Among the 3958 genes detected to be up-regulated in normal liver tissues versus normal colorectal tissues, we identified 12 liver-specific genes and found two of them, ANGPTL3 and CFHR5, were unexpressed in microdissected primary colorectal tumors without metastasis but expressed in both microdissected liver metastases and corresponding primary colorectal tumors (Fisher's exact test, P < 0.05). Genes co-expressed with ANGPTL3 and CFHR5 were significantly enriched in metabolism pathways characterizing liver tissues, including "starch and sucrose metabolism" and "drug metabolism-cytochrome P450". Conclusions: For primary CRC with liver metastasis, both the liver metastases and corresponding primary colorectal tumors may express some liver-specific genes which may help the tumor cells adapt the liver micro-environment.

引用

页码：1500 / 1505

页数：6

共 44 条

[1] Improving resectability of hepatic colorectal metastases: Expert consensus statement [J].