Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats

被引：0
作者：
Kim, Junghyun [1 ]
Lee, Yun Mi [1 ]
Kim, Chan-Sik [1 ]
Sohn, Eunjin [1 ]
Jo, Kyuhyung [1 ]
Shin, So Dam [1 ]
Kim, Jin Sook [1 ]
机构：
[1] Korea Inst Oriental Med, Herbal Med Res Div, Korean Med Based Herbal Drug Res Grp, Taejon 305811, South Korea
来源：
JOURNAL OF DIABETES RESEARCH | 2013年 / 2013卷
关键词：
METHYLGLYOXAL-INDUCED APOPTOSIS; ADVANCED GLYCATION; OXIDATIVE STRESS; DIABETIC-RETINOPATHY; LIPID-PEROXIDATION; AMINO-ACIDS; IN-VITRO; MODEL; PATHOGENESIS; ACTIVATION;
D O I：
10.1155/2013/460820
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pyruvate is an endogenous antioxidant substance. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy. To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage, we have used intravitreally methylglyoxal-(MGO-) injected rat eyes. Apoptosis of the retinal vascular cell that was stimulated by the intravitreal injection of MGO was evidently attenuated by the EP treatment. EP exerts inhibitory effect on MGO-induced vascular cell apoptosis by blocking oxidative injury. In addition, EP treatment prevented MGO-induced BRB breakage and the degradation of occludin, an important tight junction protein. These observations suggest that EP acts through an antioxidant mechanism to protect against oxidative stress-induced apoptosis in retinal vessels.
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页数：8
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