Rituximab-Induced Severe Acute Thrombocytopenia: A case Report and Review of Literature

被引：19
作者：
Dhand, Suneel [1 ]
Bahrain, Huzefa [1 ]
机构：
[1] Franklin Sq Hosp Ctr, Baltimore, MD 21237 USA
来源：
CANCER INVESTIGATION | 2008年 / 26卷 / 09期
关键词：
Rituximab; Thrombocytopenia; Mantle cell lymphoma;
D O I：
10.1080/07357900802010509
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Rituximab, an anti-CD20 monoclonal antibody, is generally a safe and well-tolerated drug. Severe acute thrombocytopenia following administration of rituximab is a rare phenomenon, with few previously reported cases in the literature. We report a case of an 84-year old male with a diagnosis of mantle cell lymphoma who suffered severe acute thrombocytopenia following rituximab infusion. A literature review of the previously published cases is also presented.
引用
收藏
页码：913 / 915
页数：3
相关论文
共 13 条
  • [1] Rituximab therapy in hematologic malignancy patients with circulating blood tumor cells: Association with increased infusion-related side effects and rapid blood tumor clearance
    Byrd, JC
    Waselenko, JK
    Maneatis, TJ
    Murphy, T
    Ward, FT
    Monahan, BP
    Sipe, MA
    Donegan, S
    White, CA
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (03) : 791 - 795
  • [2] Delayed-onset neutropenia associated with rituximab therapy
    Chaiwatanatorn, K
    Lee, N
    Grigg, A
    Filshie, R
    Firkin, F
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2003, 121 (06) : 913 - 918
  • [3] Enríquez R, 2007, CLIN EXP RHEUMATOL, V25, P345
  • [4] Acute tumor lysis syndrome induced by rituximab in diffuse large B-cell lymphoma
    Jabr, FI
    [J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2005, 82 (04) : 312 - 314
  • [5] Intestinal lymphoma perforations as a consequence of highly effective anti-CD20 antibody therapy
    Kollmar, O
    Becker, S
    Schilling, MK
    Maurer, CA
    [J]. TRANSPLANTATION, 2002, 73 (04) : 669 - 670
  • [6] Larrar Sophie, 2006, Haematologica, V91, pECR36
  • [7] Maloney DG, 1997, BLOOD, V90, P2188
  • [8] Otrock ZK, 2005, HAEMATOLOGICA, V90, P66
  • [9] Rituximab-induced acute thrombocytopenia in a patient with prolymphocytic leukemia
    Pamuk, GE
    Donmez, S
    Turgut, B
    Demir, M
    Vural, O
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2005, 78 (01) : 81 - 81
  • [10] Severe thrombocytopenia and clinical bleeding associated with rituximab infusion in a lymphoma patient with massive splenomegaly without leukemic invasion
    Rigamonti, C
    Volta, C
    Colombi, S
    Forti, L
    Savinelli, F
    Gaidano, G
    Bartoli, E
    [J]. LEUKEMIA, 2001, 15 (01) : 186 - 187
12