Synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in water using p-dodecylbenzenesulfonic acid as catalyst

被引：43

作者：

Das, Biswanath ^{[1
]}

Kashanna, Jajula ^{[1
]}

Kumar, Rathod Aravind ^{[1
]}

Jangili, Paramesh ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

MONATSHEFTE FUR CHEMIE | 2013年 / 144卷 / 02期

关键词：

Substituted imidazole; p-Dodecylbenzenesulfonic acid; Ketones; One-pot synthesis; Heterocycles; Green chemistry; ONE-POT SYNTHESIS; TETRASUBSTITUTED-IMIDAZOLES; EFFICIENT SYNTHESIS; BIOLOGICAL-ACTIVITY; 1,2-DIKETONES; ALDEHYDES; IODINE;

D O I：

10.1007/s00706-012-0770-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2,4,5-Trisubstituted imidazoles have been synthesized by treatment of benzil with aldehydes and ammonium acetate in water under reflux in the presence of p-dodecylbenzenesulfonic acid as catalyst. The same reaction using an additional amine affords 1,2,4,5-tetrasubstituted imidazoles. The products are formed in high yields within 4 h under eco-friendly conditions.

引用

页码：223 / 226

页数：4

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