A Gutsy Task: Generating Intestinal Tissue from Human Pluripotent Stem Cells

被引：34

作者：

Finkbeiner, Stacy R. ^{[1
]}

Spence, Jason R. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI USA

[3] Univ Michigan, Sch Med, Ctr Organogenesis, Ann Arbor, MI USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2013年 / 58卷 / 05期

关键词：

Organoid; Enteroid; Intestine; Pluripotent; Stem cell; Crypt; GERM LAYER FORMATION; IN-VITRO; DIRECTED DIFFERENTIATION; ENDODERM DEVELOPMENT; DEFINITIVE ENDODERM; FEEDER-FREE; EFFICIENT DIFFERENTIATION; NEURAL DIFFERENTIATION; PROGENITOR CELLS; ENDOCRINE-CELLS;

D O I：

10.1007/s10620-013-2620-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Many significant advances in our understanding of intestine development, intestinal stem cell homeostasis and differentiation have been made in recent years. These advances include novel techniques to culture primary human and mouse intestinal epithelium in three-dimensional matrices, and de novo generation of human intestinal tissue from embryonic and induced pluripotent stem cells. This short review will focus on the directed differentiation of human pluripotent stem cells into intestinal tissue, highlight novel uses of this tissue, and compare and contrast this system to primary intestinal epithelial cultures.

引用

页码：1176 / 1184

页数：9

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