Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis

被引:10
作者
Fregonezi, Guilherme [1 ]
Saldanha Araujo, Palomma Russelly [1 ]
Ferreira Macedo, Tathiana Lindemberg [1 ]
Dourado Junior, Mario Emilio [2 ]
Resqueti, Vanessa Regiane [3 ]
Dornelas de Andrade, Armele de Fatima [3 ]
机构
[1] Fed Univ Rio Grande Norte UFRN, Dept Phys Therapy, Natal, RN, Brazil
[2] Univ Fed Rio Grande do Norte, Onofre Lopes Univ Hosp, Natal, RN, Brazil
[3] Fed Univ Pernambuco UFPE, Dept Physiotherapy, Lab Cardiopulm Physiotherapy, Pernambuco, PE, Brazil
关键词
muscle weakness; neuromuscular diseases; pulmonary function test; respiratory muscles; NASAL INSPIRATORY PRESSURE; MOTOR-NEURON DISEASE; SPIROMETRY; SNIFF; DEATH; VENTILATION; WEAKNESS; VALUES; TESTS; ALS;
D O I
10.1590/S0004-282X2013000300004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: It was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects. Methods: Pulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness. Results: Twenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for Plmax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables Plmax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, Plmax and PEmax. Conclusion: In ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.
引用
收藏
页码:146 / 152
页数:7
相关论文
共 28 条
  • [1] Araujo PRS, MAXIMAL SNI IN PRESS
  • [2] Azevedo IG, 2010, TER MAN, V8, P224
  • [3] BLACK LF, 1969, AM REV RESPIR DIS, V99, P696
  • [4] Causes of death in a post-mortem series of ALS patients
    Corcia, Philippe
    Pradat, Pierre-Francois
    Salachas, Francois
    Bruneteau, Gaealle
    Le Forestier, Nadine
    Seilhean, Danielle
    Hauw, Jean-Jacques
    Meininger, Vincent
    [J]. AMYOTROPHIC LATERAL SCLEROSIS, 2008, 9 (01): : 59 - 62
  • [5] Amyotrophic lateral sclerosis:: Combined nutritional, respiratory and functional assessment
    de Carvalho Silva, Luciano Bruno
    Mourao, Lucia Figueiredo
    Silva, Ariovaldo Armando
    Freire Vieira Lima, Nubia Maria
    Almeida, Sara Regina
    Franca, Marcondes C., Jr.
    Nucci, Anamarli
    Amaya-Farfan, Jaime
    [J]. ARQUIVOS DE NEURO-PSIQUIATRIA, 2008, 66 (2B) : 354 - 359
  • [6] SPIROMETRY IN AMYOTROPHIC LATERAL SCLEROSIS
    FALLAT, RJ
    JEWITT, B
    BASS, M
    KAMM, B
    NORRIS, FH
    [J]. ARCHIVES OF NEUROLOGY, 1979, 36 (02) : 74 - 80
  • [7] Fregonezi GAF, 2011, EUR RESP J, V239
  • [8] Clinical attention and assistance profile of patients with amyotrophic lateral sclerosis
    Freire Vieira Lima, Nubia Maria
    Nucci, Anamarli
    [J]. ARQUIVOS DE NEURO-PSIQUIATRIA, 2011, 69 (2A) : 170 - 175
  • [9] Limitations of sniff nasal pressure in patients with severe neuromuscular weakness
    Hart, N
    Polkey, MI
    Sharshar, T
    Falaize, L
    Fauroux, B
    Raphaël, JC
    Lofaso, F
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (12) : 1685 - 1687
  • [10] How common are the "common" neurologic disorders?
    Hirtz, D.
    Thurman, D. J.
    Gwinn-Hardy, K.
    Mohamed, M.
    Chaudhuri, A. R.
    Zalutsky, R.
    [J]. NEUROLOGY, 2007, 68 (05) : 326 - 337