Chronic Schistosoma japonicum Infection Reduces Immune Response to Vaccine against Hepatitis B in Mice

被引:0
作者
Chen, Lin [1 ,2 ]
Liu, Wen-qi [1 ]
Lei, Jia-hui [1 ]
Guan, Fei [1 ]
Li, Man-jun [1 ]
Song, Wen-jian [3 ]
Li, Yong-long [1 ]
Wang, Ting [1 ]
机构
[1] Huazhong Univ Sci & Technol, Dept Parasitol, Tongji Med Coll, Wuhan 430074, Peoples R China
[2] Jianghan Univ, Wuhan Inst Biomed Sci, Wuhan, Peoples R China
[3] Jianghan Univ, Dept Parasitol, Wuhan, Peoples R China
关键词
PROTECTIVE EFFICACY; MANSONI INFECTION; IMMUNOGENICITY; METAANALYSIS; ACTIVATION; ANTIBODIES; CHILDREN; INFANTS;
D O I
10.1371/journal.pone.0051512
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Hepatitis B and schistosomiasis are most prevalent in Africa and Asia, and co-infections of both are frequent in these areas. The immunomodulation reported to be induced by schistosome infections might restrict immune control of hepatitis B virus (HBV) leading to more severe viral infection. Vaccination is the most effective measure to control and prevent HBV infection, but there is evidence for a reduced immune response to the vaccine in patients with chronic schistosomiasis japonica. Methodology/Principal Findings: In this paper, we demonstrate in a mouse model that a chronic Schistosoma japonicum infection can inhibit the immune response to hepatitis B vaccine (HBV vaccine) and lead to lower production of anti-HBs antibodies, interferon-gamma (IFN-gamma) and interleukin-2 (IL-2). After deworming with Praziquantel (PZQ), the level of anti-HBs antibodies gradually increased and the Th2-biased profile slowly tapered. At 16 weeks after deworming, the levels of anti-HBs antibodies and Th1/Th2 cytokines returned to the normal levels. Conclusions/Significance: The results suggest that the preexisting Th2-dominated immune profile in the host infected with the parasite may down-regulate levels of anti-HBs antibodies and Th1 cytokines. To improve the efficacy of HBV vaccination in schistosome infected humans it may be valuable to treat them with praziquantel (PZQ) some time prior to HBV vaccination. Citation: Chen L, Liu W-q, Lei J-h, Guan F, Li M-j, et al. (2012) Chronic Schistosoma japonicum Infection Reduces Immune Response to Vaccine against Hepatitis B in Mice. PLoS ONE 7(12): e51512. doi:10.1371/journal.pone.0051512
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页数:7
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