A lysosome-targeting colorimetric and fluorescent dual signal probe for sensitive detection and bioimaging of hydrogen sulfide

被引：18

作者：

Wu, Cuiyan ^{[1
,2
]}

Hu, Xiaojun ^{[1
]}

Gu, Biao ^{[1
]}

Yin, Peng ^{[1
]}

Su, Wei ^{[1
]}

Li, Yaqian ^{[1
]}

Lu, Qiujun ^{[1
]}

Zhang, Youyu ^{[1
]}

Li, Haitao ^{[1
]}

机构：

[1] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Hunan, Peoples R China

[2] Hunan Normal Univ, Coll Chem & Chem Engn, Natl & Local Joint Engn Lab New Petrochem Mat & F, Changsha 410081, Hunan, Peoples R China

来源：

ANALYTICAL METHODS | 2018年 / 10卷 / 06期

基金：

中国国家自然科学基金;

关键词：

SELECTIVE DETECTION; LIVING CELLS; H2S; RECOGNITION; CYSTEINE; COPPER;

D O I：

10.1039/c7ay02492d

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4morpholinophenyl)-4H-chromen-4-one (DMC), for the detection of hydrogen sulfide (H2S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H2S, a significant enhancement in the fluorescence was observed along with a distinct color change from yellow to colorless. This probe shows a low background spectroscopic signal, large Stokes shift, good sensitivity, and high selectivity towards H2S. Most importantly, DMC has low toxicity and excellent cell permeability, and could be applied to visualizing H2S in lysosomes.

引用

页码：604 / 610

页数：7

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