Visible-Light Induced Isoindoles Formation To Trigger Intermolecular Diels-Alder Reactions in the Presence of Air

被引：31
作者：
Lin, Chao
Zhen, Le
Cheng, Yong
Du, Hong-Jin
Zhao, Hui
Wen, Xiaoan
Kong, Ling-Yi
Xu, Qing-Long [1 ]
Sun, Hongbin
机构：
[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 11期
基金：
中国国家自然科学基金;
关键词：
CHEMISTRY; DERIVATIVES; GENERATION; CATALYSIS;
D O I：
10.1021/acs.orglett.5b01078
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Visible-light induced isoindole formation triggered an intermolecular Diels-Alder reaction with dienophiles such as acetylenedicarboxylate and maleimides in the presence of air. The reaction resulted in excellent diastereoselctivity and high yields under mild reaction conditions. This protocol provides an atom-economical, transition-metal-free (TM-free) and straightforward approach to structurally diverse bridged-ring heterocycles from easily accessible molecules.
引用
收藏
页码：2684 / 2687
页数：4
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