Synthesis of (Z)-2-[quinazolin-4(3H)-ylidene]acetonitriles by the reaction of N-(2-cyanophenyl)alkanimidates with 2-lithioacetonitrile

被引：1

作者：

Kobayashi, Kazuhiro ^{[1
]}

Ukon, Takahiro ^{[1
]}

Nakano, Hidenari ^{[1
]}

Fukamachi, Shuhei ^{[1
]}

Konishi, Hisatoshi ^{[1
]}

机构：

[1] Tottori Univ, Div Appl Chem, Dept Chem & Biotechnol, Grad Sch Engn, Tottori 6808552, Japan

来源：

SYNTHESIS-STUTTGART | 2008年 / 18期

关键词：

carbanions; fused-ring system; heterocycles; nitriles; ring closure; quinazoline;

D O I：

10.1055/s-2008-1067235

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparation of (Z)-2-[quinazolin-4(3H) ylidene]acetonitriles has been achieved in one pot by addition of 2: lithioacetonitrile to the cyano carbon of N-(2-cyanophenyl)alkanimidates, followed by intramolecular attack of the resulting imino anion on the imidate carbon with loss of alkoxide and subsequent tautomerization.

引用

页码：2874 / 2878

页数：5

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