Mind the Gap: Potential for Rebounds during Antiangiogenic Treatment Breaks

被引：13

作者：

Ebos, John M. L. ^{[1
]}

Pili, Roberto ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Genitourinary Program, Buffalo, NY 14263 USA

来源：

CLINICAL CANCER RESEARCH | 2012年 / 18卷 / 14期

关键词：

RENAL-CELL CARCINOMA; SUNITINIB; PROGRESSION; REGROWTH; THERAPY; GROWTH;

D O I：

10.1158/1078-0432.CCR-12-1459

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

VEGF pathway inhibitors have shown benefits in many cancers, yet many (often controversial) questions remain about whether vascular and tumor regrowth can occur when therapy is stopped. Marked increases in endothelial cell proliferation could play a role in putative rebounds, potentially influencing overall efficacy, dosing schedules, and presurgical intervention strategies. Clin Cancer Res; 18(14); 3719-21. (C)2012 AACR.

引用

页码：3719 / 3721

页数：3

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