The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review

被引：45

作者：

Boeckx, Nele ^{[1
,2
,3
]}

Janssens, Katleen ^{[1
]}

Van Camp, Guy ^{[1
,2
,3
]}

Rasschaert, Marika ^{[4
]}

Papadimitriou, Konstantinos ^{[4
]}

Peeters, Marc ^{[1
,4
]}

Op de Beeck, Ken ^{[1
,2
,3
]}

机构：

[1] Univ Antwerp, Ctr Oncol Res CORE, Univ Pl 1, B-2610 Antwerp, Belgium

[2] Univ Antwerp, Ctr Med Genet, Prins Boudewijnlaan 43-6, B-2650 Edegem, Belgium

[3] Antwerp Univ Hosp, Prins Boudewijnlaan 43-6, B-2650 Edegem, Belgium

[4] Antwerp Univ Hosp, Dept Oncol, Wilrijkstr 10, B-2650 Edegem, Belgium

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2018年 / 121卷

关键词：

Primary tumor location; Predictive value; Anti-EGFR therapy; Anti-VEGF therapy; Biomarkers; ISLAND METHYLATOR PHENOTYPE; SIDED COLON-CANCER; MESSENGER-RNA EXPRESSION; BRAF V600E MUTATION; CLINICOPATHOLOGICAL FEATURES; MICROSATELLITE INSTABILITY; MOLECULAR-FEATURES; BEVACIZUMAB EFFECTIVENESS; MICROBIOTA ORGANIZATION; FUSOBACTERIUM-NUCLEATUM;

D O I：

10.1016/j.critrevonc.2017.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. It has been reported that left- and right-sided CRC harbor varying disease characteristics, which leads to a difference in prognosis and response to therapy. Recently, there have been retrospective studies about tumor location in metastatic CRC (mCRC) and its potential to predict the effect of anti-vascular endothelial growth factor and anti-epidermal growth factor receptor (anti-EGFR) therapies. In this review, we provide a comprehensive overview of the latest trials studying the predictive value of primary tumor location in mCRC and discuss biomarkers that might be associated with the differences in treatment response. Although data need to be interpreted with caution due to the absence of randomized trials stratified based on tumor location, patients with left-sided CRC seem to benefit more from anti-EGFR therapy than patients with right-sided CRC. Further clinical trials, stratified for tumor location, are warranted.

引用

页码：1 / 10

页数：10

共 113 条

[1]

Adams R. A, 2012, J CLIN ONCOL S30, V30

[2] Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern [J].

Al-Shamsi, Humaid O. ;

Jones, Jeremy ;

Fahmawi, Yazan ;

Dahbour, Ibrahim ;

Tabash, Aziz ;

Abdel-Wahab, Reham ;

Abousamra, Ahmed O. S. ;

Shaw, Kenna R. ;

Xiao, Lianchun ;

Hassan, Manal M. ;

Kipp, Benjamin R. ;

Kopetz, Scott ;

Soliman, Amr S. ;

McWilliams, Robert R. ;

Wolff, Robert A. .

JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2016, 7 (06) :882-+

[3]

[Anonymous], 2017, NCCN GUID COL CANC V

[4]

[Anonymous], 2011, PATHOL RES INT

[5] Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials [J].

Arnold, D. ;

Lueza, B. ;

Douillard, J. -Y. ;

Peeters, M. ;

Lenz, H. -J. ;

Venook, A. ;

Heinemann, V. ;

Van Cutsem, E. ;

Pignon, J. -P. ;

Tabernero, J. ;

Cervantes, A. ;

Ciardiello, F. .

ANNALS OF ONCOLOGY, 2017, 28 (08) :1713-1729

[6] Toward a Molecular Classification of Synchronous Colorectal Cancer: Clinical and Molecular Characterization [J].

Arriba, Maria ;

Sanchez, Ricardo ;

Rueda, Daniel ;

Gomez, Laura ;

Garcia, Juan L. ;

Rodriguez, Yolanda ;

Antonio Pajares, Jose ;

Perez, Jessica ;

Urioste, Miguel ;

Gonzalez Sarmiento, Rogelio ;

Perea, Jose .

CLINICAL COLORECTAL CANCER, 2017, 16 (01) :31-37

[7]

Bendardaf R, 2008, ANTICANCER RES, V28, P3865

[8] Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival [J].

Benedix, Frank ;

Kube, Rainer ;

Meyer, Frank ;

Schmidt, Uwe ;

Gastinger, Ingo ;

Lippert, Hans .

DISEASES OF THE COLON & RECTUM, 2010, 53 (01) :57-64

[9] Molecular spectrum of KRAS, BRAF, and PIK3CA gene mutation: determination of frequency, distribution pattern in Indian colorectal carcinoma [J].

Bisht, Swati ;

Ahmad, Firoz ;

Sawaimoon, Satyakam ;

Bhatia, Simi ;

Das, Bibhu Ranjan .

MEDICAL ONCOLOGY, 2014, 31 (09) :1-13

[10] Primary tumor sidedness has an impact on prognosis and treatment outcome in metastatic colorectal cancer: results from two randomized first-line panitumumab studies [J].

Boeckx, N. ;

Koukakis, R. ;

de Beeck, K. Op ;

Rolfo, C. ;

Van Camp, G. ;

Siena, S. ;

Tabernero, J. ;

Douillard, J. -Y. ;

Andre, T. ;

Peeters, M. .

ANNALS OF ONCOLOGY, 2017, 28 (08) :1862-1868

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