CIDE Proteins and Lipid Metabolism

被引：158

作者：

Xu, Li ^{[1
,2
]}

Zhou, Linkang ^{[1
]}

Li, Peng ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China

[2] Chinese Acad Agr Sci, Feed Res Inst, Minist Agr, Key Lab Feed Biotechnol, Beijing 100193, Peoples R China

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2012年 / 32卷 / 05期

基金：

中国国家自然科学基金;

关键词：

cell death-inducing DNA fragmentation factor 45-like effector; lipid droplet; lipid metabolism; metabolic disorders; very low-density lipoprotein; LOW-DENSITY LIPOPROTEINS; DIFFERENTIATION-RELATED PROTEIN; TRIGLYCERIDE TRANSFER PROTEIN; FAT-SPECIFIC PROTEIN-27; LEPTIN-DEFICIENT MICE; BROWN ADIPOSE-TISSUE; APOLIPOPROTEIN-B; ENDOPLASMIC-RETICULUM; INSULIN SENSITIVITY; MCA-RH7777; CELLS;

D O I：

10.1161/ATVBAHA.111.241489

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid homeostasis is maintained through the coordination of lipid metabolism in various tissues, including adipose tissue and the liver. The disruption of lipid homeostasis often results in the development of metabolic disorders such as obesity, diabetes mellitus, liver steatosis, and cardiovascular diseases. Cell death-inducing DNA fragmentation factor 45-like effector family proteins, including Cidea, Cideb, and Fsp27 (Cidec), are emerging as important regulators of various lipid metabolic pathways and play pivotal roles in the development of metabolic disorders. This review summarizes the latest cell death-inducing DNA fragmentation factor 45-like effector protein discoveries related to the control of lipid metabolism, with emphasis on the role of these proteins in lipid droplet growth in adipocytes and in the regulation of very low-density lipoprotein lipidation and maturation in hepatocytes. (Arterioscler Thromb Vasc Biol. 2012; 32: 1094-1098.)

引用

页码：1094 / 1098

页数：5

共 71 条

[1] ADP-ribosylation factor 1 and its activation of phospholipase D are important for the assembly of very low density lipoproteins [J].