MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells

被引：134
作者：
Long, Mei-Jing [1 ,2 ]
Wu, Fu-Xia [1 ,2 ]
Li, Pu [3 ]
Liu, Min [1 ,2 ]
Li, Xin [1 ,2 ]
Tang, Hua [1 ,2 ]
机构：
[1] Tianjin Med Univ, Tianjin Life Sci Res Ctr, Tianjin, Peoples R China
[2] Tianjin Med Univ, Basic Med Sch, Tianjin, Peoples R China
[3] Tianjin Cent Hosp Gynecol Obstet, Tianjin, Peoples R China
来源：
CANCER LETTERS | 2012年 / 324卷 / 02期
关键词：
MicroRNA-10a; CHL1; Cervical cancer; Migration; Invasion; TUMOR-GROWTH; IN-VITRO; EXPRESSION; ADHESION; FAMILY; PROGRESSION; MECHANISM; ONCOGENE; MEMBER;
D O I：
10.1016/j.canlet.2012.05.022
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) play an important role in cancer initiation, progression and metastasis by regulating their target genes. Here, we found microRNA-10a (miR-10a) is upregulated in human cervical cancer and promotes the colony formation activity, migration and invasion of HeLa and C33A cells. Subsequently. CHL1 is confirmed as a target of miR-10a and is negatively regulated by miR-10a at mRNA and protein levels. Furthermore, knockdown of CHL1 expression results in increased colony formation activity, migration and invasion. Finally, overexpression of CHL1 lacked the 3'UTR abolished the effects of miR-10a. Our results may provide a strategy for blocking tumor metastasis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：186 / 196
页数：11
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