Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer

被引：39
作者：
He, Liang [1 ,2 ]
Chu, Dake [1 ,3 ]
Li, Xia [4 ]
Zheng, Jianyong [1 ]
Liu, Shanhong [5 ]
Li, Jipeng [1 ]
Zhao, Qingchuan [1 ]
Ji, Gang [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xian 710032, Peoples R China
[2] Lanzhou Mil Dist Hosp Urumqi, Dept Gen Surg, Urumqi, Xinjiang, Peoples R China
[3] Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Biochem & Mol Biol, Xian 710032, Peoples R China
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
[5] Northern Hosp, Dept Emergency, Xian, Peoples R China
来源：
DIGESTIVE DISEASES AND SCIENCES | 2013年 / 58卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Matrix metalloproteinase-14; Gastric cancer; Immunohistochemistry; Prognosis; TUMOR INVASION; INHIBITION; MMP-14; EXPRESSION; 5-FLUOROURACIL; CHEMOTHERAPY; PHENOTYPE; CELLS;
D O I：
10.1007/s10620-012-2513-9
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor. The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer. Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients. MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren's classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression. The present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.
引用
收藏
页码：1264 / 1270
页数：7
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