Subtle retinal pathology in amyotrophic lateral sclerosis

被引：54

作者：

Ringelstein, Marius ^{[1
]}

Albrecht, Philipp ^{[1
]}

Suedmeyer, Martin ^{[1
,2
]}

Harmel, Jens ^{[1
]}

Mueller, Ann-Kristin ^{[1
]}

Keser, Nazmiye ^{[1
]}

Finis, David ^{[3
]}

Ferrea, Stefano ^{[1
,2
]}

Guthoff, Rainer ^{[3
]}

Schnitzler, Alfons ^{[1
,2
]}

Hartung, Hans-Peter ^{[1
]}

Methner, Axel ^{[1
,4
]}

Aktas, Orhan ^{[1
]}

机构：

[1] Heinrich Heine Univ, Fac Med, Dept Neurol, Moorenstr 5, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ, Fac Med, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany

[3] Heinrich Heine Univ, Fac Med, Dept Ophthalmol, Dusseldorf, Germany

[4] Johannes Gutenberg Univ Mainz, Fac Med, Dept Neurol, Mainz, Germany

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2014年 / 1卷 / 04期

关键词：

D O I：

10.1002/acn3.46

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyotrophic lateral sclerosis (ALS) is characterized by neuro-ophthalmological abnormalities beyond disturbed oculomotor control such as decreased visual acuity and disturbed visual evoked potentials. Here we report retinal alterations in a cohort of 24 patients with clinically definite (n = 20) or probable (n = 4) ALS as compared to matched controls. High-resolution spectral domain optical coherence tomography with retinal segmentation revealed a subtle reduction in the macular thickness and the retinal nerve fiber layer (RNFL) as well as a marked thinning of the inner nuclear layer (INL). Our data indicate an unprecedented retinal damage pattern and suggest neurodegeneration beyond the motor system in this disease.

引用

页码：290 / 297

页数：8

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