Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis

被引：145

作者：

Berkowitz, Loni ^{[1
,2
]}

Schultz, Barbara M. ^{[1
]}

Salazar, Geraldyne A. ^{[1
]}

Pardo-Roa, Catalina ^{[1
]}

Sebastian, Valentina P. ^{[1
]}

Alvarez-Lobos, Manuel M. ^{[2
]}

Bueno, Susan M. ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Millennium Inst Immunol & Immunotherapy, Dept Genet Mol & Microbiol, Santiago, Chile

[2] Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Santiago, Chile

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

关键词：

cigarette smoking; gastrointestinal inflammation; inflammatory bowel disease; ulcerative colitis; Crohn's disease; BOWEL-DISEASE; INTESTINAL INFLAMMATION; EPITHELIAL APOPTOSIS; GENETIC ASSOCIATION; OXIDATIVE STRESS; HEME OXYGENASE-1; IMMUNOGLOBULIN-G; TIGHT JUNCTIONS; NICOTINE GUM; PANETH CELLS;

D O I：

10.3389/fimmu.2018.00074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer, Crohn's disease (CD), and several cancers. The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response. Paradoxically, cigarette smoking is a protective factor for the development and progression of ulcerative colitis (UC). UC and CD represent the two most important conditions of inflammatory bowel diseases, and share several clinical features. The opposite effects of smoking on these two conditions have been a topic of great interest in the last 30 years, and has not yet been clarified. In this review, we summarize the most important and well-understood effects of smoking in the gastrointestinal tract; and particularly, in intestinal inflammation, discussing available studies that have addressed the causes that would explain the opposite effects of smoking in CD and UC.

引用

页数：10

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