The Role of MicroRNAs in Influencing Body Growth and Development

被引：32
|
作者：
Cirillo, Francesca [1 ]
Catellani, Cecilia [1 ]
Lazzeroni, Pietro [1 ]
Sartori, Chiara [1 ]
Street, Maria Elisabeth [1 ]
机构：
[1] Azienda USL IRCCS Reggio Emilia, Dept Mother & Child, Viale Risorgimento 80, IT-42123 Reggio Emilia, Italy
来源：
HORMONE RESEARCH IN PAEDIATRICS | 2020年 / 93卷 / 01期
关键词：
Growth; Development; MicroRNA; Growth hormone; Insulin-like growth factor-I; Body size; POSTTRANSCRIPTIONAL REGULATION; HORMONE; EXPRESSION; TARGET; PATHWAYS; MIRNAS; DICER; AXIS; GENE; IDENTIFICATION;
D O I：
10.1159/000504669
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Body growth and development are regulated among others by genetic and epigenetic factors. MicroRNAs (miRNAs) are epigenetic regulators of gene expression that act at the post-transcriptional level, thereby exerting a strong influence on regulatory gene networks. Increasing studies suggest the importance of miRNAs in the regulation of the growth plate and growth hormone (GH)-insulin-like growth factor (IGF) axis during the life course in a broad spectrum of animal species, contributing to longitudinal growth. This review summarizes the role of miRNAs in regulating growth in different in vitro and in vivo models acting on GH, GH receptor (GHR), IGFs, and IGF1R genes besides current knowledge in humans, and highlights that this regulatory system is of importance for growth.
引用
收藏
页码：7 / 15
页数：9
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