The Role of MicroRNAs in Influencing Body Growth and Development

被引：32
|
作者：
Cirillo, Francesca [1 ]
Catellani, Cecilia [1 ]
Lazzeroni, Pietro [1 ]
Sartori, Chiara [1 ]
Street, Maria Elisabeth [1 ]
机构：
[1] Azienda USL IRCCS Reggio Emilia, Dept Mother & Child, Viale Risorgimento 80, IT-42123 Reggio Emilia, Italy
来源：
HORMONE RESEARCH IN PAEDIATRICS | 2020年 / 93卷 / 01期
关键词：
Growth; Development; MicroRNA; Growth hormone; Insulin-like growth factor-I; Body size; POSTTRANSCRIPTIONAL REGULATION; HORMONE; EXPRESSION; TARGET; PATHWAYS; MIRNAS; DICER; AXIS; GENE; IDENTIFICATION;
D O I：
10.1159/000504669
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Body growth and development are regulated among others by genetic and epigenetic factors. MicroRNAs (miRNAs) are epigenetic regulators of gene expression that act at the post-transcriptional level, thereby exerting a strong influence on regulatory gene networks. Increasing studies suggest the importance of miRNAs in the regulation of the growth plate and growth hormone (GH)-insulin-like growth factor (IGF) axis during the life course in a broad spectrum of animal species, contributing to longitudinal growth. This review summarizes the role of miRNAs in regulating growth in different in vitro and in vivo models acting on GH, GH receptor (GHR), IGFs, and IGF1R genes besides current knowledge in humans, and highlights that this regulatory system is of importance for growth.
引用
收藏
页码：7 / 15
页数：9
相关论文
共 50 条
  • [1] microRNAs ROLE IN HEART DEVELOPMENT
    Zajkowska, Agnieszka
    Malecki, Maciej
    POSTEPY BIOLOGII KOMORKI, 2015, 42 (01) : 107 - 126
  • [2] Role of microRNAs in schistosomes and schistosomiasis
    Zhu, Lihui
    Liu, Jinming
    Cheng, Guofeng
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2014, 4
  • [3] Regulation of body growth by microRNAs
    Lui, Julian C.
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2017, 456 (0C) : 2 - 8
  • [4] Dynamics and role of MicroRNAs during mammalian follicular development
    Gebremedhn, S.
    Pandey, H. O.
    Salilew-Wondim, D.
    Hoelker, M.
    Schellander, K.
    Tesfaye, D.
    ANIMAL REPRODUCTION, 2016, 13 (03) : 257 - 263
  • [5] The role of blood flow and microRNAs in blood vessel development
    Liu, Dong
    Krueger, Janna
    Le Noble, Ferdinand
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2011, 55 (4-5) : 419 - 429
  • [6] Functions of microRNAs in Drosophila development
    Jones, Christopher I.
    Newbury, Sarah F.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2010, 38 : 1137 - 1143
  • [7] lncRNAs and microRNAs with a role in cancer development
    Liz, Julia
    Esteller, Manel
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2016, 1859 (01): : 169 - 176
  • [8] Functional Role of MicroRNAs in Thymocyte Development
    Hu, Lin
    Mao, Ling
    Liu, Shiming
    Zhao, Juanjuan
    Chen, Chao
    Guo, Mengmeng
    He, Zhixu
    Yang, Jie
    Xu, Wei
    Xu, Lin
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2019, 178 (04) : 315 - 322
  • [9] The role of microRNAs in cardiac development and regenerative capacity
    Katz, Michael G.
    Fargnoli, Anthony S.
    Kendle, Andrew P.
    Hajjar, Roger J.
    Bridges, Charles R.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2016, 310 (05): : H528 - H541
  • [10] MicroRNAs in Retinal Development
    Reh, Thomas A.
    Hindges, Robert
    ANNUAL REVIEW OF VISION SCIENCE, VOL 4, 2018, 4 : 25 - 44
12345