Facile enantioselective synthesis of a key homoallylic alcohol building block for polyketide synthesis:: TiF4-BINOL catalyzed allylsilylation with allyl trimethylsilane

被引：38

作者：

Bode, JW ^{[1
]}

Gauthier, DR ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Zentrum, Organ Chem Lab, CH-8092 Zurich, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 24期

关键词：

D O I：

10.1039/b107995f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The titanium fluoride-BINOL catalyzed asymmetric allylsilylation of alpha,alpha -disubstituted aldehydes provides facile access to highly functionalized, chiral building blocks, which following simple recrystallization affords a key versatile starting material for polyketide synthesis in 96% ee.

引用

页码：2560 / 2561

页数：2

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