Electrospray-differential mobility analysis of bionanoparticles

被引：70

作者：

Guha, Suvajyoti ^{[1
,2
]}

Li, Mingdong ^{[1
,2
]}

Tarlov, Michael J. ^{[2
]}

Zechariah, Michael R. ^{[1
,2
]}

机构：

[1] Univ Maryland, College Pk, MD 20742 USA

[2] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2012年 / 30卷 / 05期

关键词：

electrospray-differential mobility analysis; viruses; proteins; gold-protein conjugates; CONDENSATION PARTICLE COUNTER; FLIGHT MASS-SPECTROMETRY; MALDI-TOF-MS; ION-MOBILITY; ELECTROPHORETIC MOBILITY; MOLECULAR ANALYZER; GLOBULAR-PROTEINS; VIRUS; NANOPARTICLES; COMPLEXES;

D O I：

10.1016/j.tibtech.2012.02.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Electrospray-differential mobility analysis (ES-DMA) is a versatile technique used to aerosolize bionanoparticles and measure their electrical mobility at ambient conditions. ES-DMA is similar to electrospray-mass spectrometry (ES-MS), but measures the effective particle size, rather than mass. It has a wide range of applications and nominally can be used to characterize biomolecules and nanoparticles ranging in size from a few nanometers (similar to 3 nm) to several hundred nanometers, to obtain multimodal size distributions in minutes. Although both the ES and the DMA are mature technologies, they are finding increased use in combination to characterize particles in liquids. In this paper, we review ES-DMA, and how it has recently been used to characterize bionanoparticles such as polymers, proteins, viruses, bacteriophages and nanoparticle-biomolecule conjugates.

引用

页码：291 / 300

页数：10

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