Stability-indicative HPLC determination of donepezil hydrochloride in tablet dosage form

被引：11

作者：

Singh, B. K. ^{[1
]}

Srivastava, R. K. ^{[2
]}

Kumar, S. Senthil ^{[3
]}

Dutta, P. K. ^{[1
]}

机构：

[1] Motilal Nehru Natl Inst Technol, Dept Chem, Allahabad 211002, Uttar Pradesh, India

[2] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India

[3] Erode Coll Pharm, Erode 638041, Tamil Nadu, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2012年 / 45卷 / 12期

关键词：

Donepezil hydrochloride; HPLC; tablets; dosage form; validation; LIQUID-CHROMATOGRAPHY; PLASMA; ENANTIOMERS; E2020;

D O I：

10.1007/s11094-012-0721-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Asimple, selective, precise and stability-indicative high-performance liquid chromatography (HPLC) method of analysis of donepezil hydrochloride in tablet dosage form has been developed and validated. The drug undergoes degradation under acidic, basic, peroxide, photochemical and thermal conditions. The method has been statistically validated for linearity, accuracy, precision, limit of detection, limit of quantitation, solution stability, and selectivity according to ICH recommendations. Due to its simplicity and accuracy, the method can be used for routine drug quality control.

引用

页码：766 / 770

页数：5

共 12 条

[1] Stability indicating methods for determination of donepezil hydrochloride according to ICH guidelines [J].