Immunity against prions?

被引：16

作者：

Heppner, FL

Arrighi, I

Kalinke, U

Aguzzi, A

机构：

[1] EMBL, Mouse Biol Programme, I-00016 Monterotondo, Italy

[2] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 11期

关键词：

D O I：

10.1016/S1471-4914(01)02182-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several recent reports indicate that antibodies directed against the cellular form of the prion protein, PrPc, might eliminate the transmissible agent of spongiform encephalopathies (the prion) from scrapie-infected cells in vitro, and that a humoral immune response could prevent scrapie pathogenesis in vivo. These findings suggest that immunotherapeutical intervention against prion diseases is not unattainable. Will vaccines and post-exposure strategies based on antibodies ever prove useful against scrapie, bovine spongiform encephalopathy (BSE), or Creutzfeldt-Jakob disease?.

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收藏

页码：477 / 479

页数：3

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