Balneotherapy decreases mechanical hyperalgesia by reversing BDNF and NOS2 immunocontent in spinal cord of mice with neuropathic pain

被引：4
作者：
de Brito, Romulo Nolasco [1 ,2 ]
Ludtke, Daniela D. [1 ,2 ]
de Oliveira, Bruna Hoffmann [1 ,2 ]
Galassi, Taynah de Oliveira [1 ,2 ]
Fernandes, Paula Franson [1 ,2 ]
Van den Berge, Sarah [1 ]
Inoue Salgado, Afonso Shiguemi [1 ,2 ,3 ]
Cidral-Filho, Francisco Jose [1 ,2 ]
Horewicz, Veronica Vargas [1 ,2 ]
Bobinski, Franciane [1 ,2 ]
Martins, Daniel Fernandes [1 ,2 ]
机构：
[1] Univ Santa Catarina, Expt Neurosci Lab LaNEx, Palhoca, SC, Brazil
[2] Univ Santa Catarina, Postgrad Program Hlth Sci, Palhoca, SC, Brazil
[3] Ctr Univ Filadelfia, Integrat Phys Therapy Residency, Londrina, Parana, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 348卷
关键词：
Balneotherapy; Chronic pain; Immersion therapy; Thermalism; Sciatic nerve injury; OXIDE SYNTHASE GENE; NEUROTROPHIC FACTOR; ANIMAL-MODEL; MURINE MODEL; SPA THERAPY; MOUSE MODEL; RADON; INJURY; EXPRESSION; EXERCISE;
D O I：
10.1016/j.jneuroim.2020.577360
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the last decades, balneotherapy or thermalism has been used for health promotion and in the treatment of inflammatory and chronic processes. We found that balneotherapy reduced mechanical hyperalgesia, as well the increase of BDNF and NOS2 levels in the spinal cord, while increased BDNF and NOS1 in the paw. The data presented herein demonstrated for the first time in a murine model of neuropathic pain, the analgesic effect of balneotherapy with the water from the natural springs of Santo Amaro da Imperatriz-Brazil. Nevertheless, future clinical trials should be conducted to test the effectiveness of balneotherapy in neuropathic pain patients.
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页数：10
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