The Immunobiology of the Interleukin-12 Family: Room for Discovery

被引：365
作者：
Wojno, Elia D. Tait [1 ,2 ]
Hunter, Christopher A. [3 ]
Stumhofer, Jason S. [4 ]
机构：
[1] Cornell Univ, Coll Vet Med, Baker Inst Anim Hlth, 235 Hungerford Hill Rd, Ithaca, NY 14853 USA
[2] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, 235 Hungerford Hill Rd, Ithaca, NY 14853 USA
[3] Univ Penn, Sch Vet Med, Dept Pathobiol, 380 South Univ Ave, Philadelphia, PA 19104 USA
[4] Univ Arkansas Med Sci, Dept Microbiol & Immunol, 4301 West Markham St, Little Rock, AR 72205 USA
来源：
IMMUNITY | 2019年 / 50卷 / 04期
基金：
美国国家卫生研究院;
关键词：
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; IFN-GAMMA PRODUCTION; IL-12; P40; HOMODIMER; ACTIVE RHEUMATOID-ARTHRITIS; STIMULATORY FACTOR NKSF; REGULATORY T-CELLS; INDUCED GENE 3; CUTTING EDGE; SIGNAL TRANSDUCER;
D O I：
10.1016/j.immuni.2019.03.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation degrees understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of cancer, infection, and inflammatory diseases. Consequently, many facets of their biology are being therapeutically targeted. Here, we review the landmark discoveries in this field, the combinatorial biology inherent to this family, and how patient datasets have underscored the critical role of these pathways in human disease. We present significant knowledge gaps, including how similar signals from these cytokines can mediate distinct outcomes, and discuss how a better understanding of the biology of the IL-12 family provides new therapeutic opportunities.
引用
收藏
页码：851 / 870
页数：20
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