Natural product coumarins that inhibit human carbonic anhydrases

被引：94

作者：

Davis, Rohan A. ^{[1
]}

Vullo, Daniela ^{[2
]}

Maresca, Alfonso ^{[2
]}

Supuran, Claudiu T. ^{[2
]}

Poulsen, Sally-Ann ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Nathan, Qld 4111, Australia

[2] Univ Florence, Lab Chim Bioinorgan, I-50019 Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

Coumarin; Carbonic anhydrase; Natural product; Sulfonamide; CA IX; CA XII; CA VII; DIDEMNUM-CHARTACEUM; SKIN SENSITIZATION; MURRAYA-PANICULATA; GEIJERA-PARVIFLORA; MASS-SPECTROMETRY; DRUG DISCOVERY; CONSTITUENTS; BARK; XII; IX;

D O I：

10.1016/j.bmc.2012.07.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products (NPs) have proven to be an invaluable source of new chemotherapies yet very few have been explored to source small molecule carbonic anhydrase (CA) inhibitors. CA enzymes underpin physiological pH and are critical to the progression of several diseases including cancer. The present study is the first to more widely investigate NP coumarins for CA inhibition following the recent discovery of a NP coumarin CA inhibitor. We assembled a NP library comprising 24 plant coumarins (compounds 4-27) and three ascidian coumarins (compounds 28-30) that together provide a diverse collection of structures containing the coumarin pharmacophore. This library was then evaluated for inhibition of six human CA isozymes (CAs I, II, VII, IX, XII and XIII) and a broad range of inhibition and isozyme selectivity profiles were evident. Our findings provide a platform to support further evaluation of NPs for the discovery of new chemotypes that inhibit disease relevant CA enzymes. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1539 / 1543

页数：5

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