Delivery Systems and Local Administration Routes for Therapeutic siRNA

被引：87

作者：

Moura de Carvalho Vicentini, Fabiana Testa ^{[1
]}

Borgheti-Cardoso, Livia Neves ^{[1
]}

Depieri, Livia Vieira ^{[1
]}

Mano, Danielle de Macedo ^{[1
]}

Abelha, Thais Fedatto ^{[1
]}

Petrilli, Raquel ^{[1
]}

Lopes Badra Bentley, Maria Vitoria ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

PHARMACEUTICAL RESEARCH | 2013年 / 30卷 / 04期

关键词：

delivery systems; local administration routes; siRNA; SMALL INTERFERING RNA; SINGLE-CELL ELECTROPORATION; OF-THE-ART; DRUG-DELIVERY; GENE-EXPRESSION; ANTISENSE OLIGONUCLEOTIDES; OCULAR NEOVASCULARIZATION; INTRACELLULAR DELIVERY; DENDRITIC CELLS; ALOPECIA-AREATA;

D O I：

10.1007/s11095-013-0971-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored.

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收藏

页码：915 / 931

页数：17

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