New derivatives of benzimidazole and their antimicrobial activity

被引：6

作者：

Cetinkaya, E ^{[1
]}

Alici, B ^{[1
]}

Gök, Y ^{[1
]}

Durmaz, R ^{[1
]}

Günal, S ^{[1
]}

机构：

[1] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44069 Malatya, Turkey

来源：

JOURNAL OF CHEMOTHERAPY | 1999年 / 11卷 / 02期

关键词：

antimicrobials; benzimidazole; benzothiazole; benzoxazole derivatives;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Azolium salts and neutral 2-aryl derivatives of benzimidazole, benzothiazole and benzoxazole were synthesized and compounds were identified by H-1 and C-13 NMR spectroscopy and microanalytical methods. In this work the salts I and the neutral compounds 2 were evaluated for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals. The compounds If, Ig, Il, Im, In, 2a, 2b, 2c, 2e, 2f showed antimicrobial activity against Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals, with minimum inhibitory concentrations (MICs) ranging between 50 to 200 mu g/mL. Compounds If, Ig, 11, Im, 2b, 2e showed the highest activity. Benzothiazolium and benzoxazolium salts were more active than 1,3-disubstituted benzimidazolium salts and neutral 2-substituted benzimidazole, benzothiazole and benzoxazole derivatives.

引用

页码：83 / 89

页数：7

共 20 条

[1] Alici B, 1997, HETEROCYCLES, V45, P29
[2] ALICI B, 1996, J CHEM RES S, V12, P516
[3] BALDWIN EJ, 1974, J AM CHEM SOC, V96, P591
[4] Cetinkaya, 1997, TURK J MED SCI, V27, P59
[5] Cetinkaya B, 1996, ARZNEIMITTEL-FORSCH, V46, P821
[6] Cetinkaya B, 1996, ARZNEIMITTEL-FORSCH, V46, P1154
[7] CARBENE COMPLEXES .24. PREPARATION AND CHARACTERIZATION OF 2 ENETETRAMINE-DERIVED CARBENERHODIUM(I) CHLORIDE COMPLEXES RHCL(L(R))(3) AND [RHCL(COD)L(R)] (L(R)=DCN(ME)CU(CH)(4)CNME-O) AND THE PREPARATION AND X-RAY STRUCTURES OF THE ENETETRAMINE L(2)(R) AND ITS SALT [L(2)(R)][BF4](2)
CETINKAYA, E
HITCHCOCK, PB
KUCUKBAY, H
LAPPERT, MF
ALJUAID, S
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1994, 481 (01) : 89 - 95
[8] CETINKAYA E, 1992, J CHEM SOC PERK T, V1, P561
[9] CHARLSON JA, 1973, CARBOHYD RES, V29, P89
[10] The total synthesis of UK-1
DeLuca, MR
Kerwin, SM
[J]. TETRAHEDRON LETTERS, 1997, 38 (02) : 199 - 202

← 1 2 →