In vitro electro-mechanical characterization of human knee articular cartilage of different degeneration levels: A comparison with ICRS and Mankin scores

被引：30

作者：

Abedian, Reza ^{[1
]}

Willbold, Elmar ^{[1
]}

Becher, Christoph ^{[2
]}

Hurschler, Christof ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Orthopaed Surg, Lab Biomech & Biomat, Hannover, Germany

[2] Hannover Med Sch, Dept Orthopaed Surg, Hannover, Germany

来源：

JOURNAL OF BIOMECHANICS | 2013年 / 46卷 / 07期

关键词：

Streaming potential integrals (SPI); Cartilage degeneration; Mechanical properties; Parameter identification; ICRS/Mankin score; STREAMING POTENTIALS; BIPHASIC INDENTATION; IONIC-STRENGTH; COMPRESSION; DEGRADATION; HISTOLOGY;

D O I：

10.1016/j.jbiomech.2013.02.004

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In the present study, the electro-mechanical properties of human knee articular cartilage were measured in vitro. An arthroscopic measurement tool was used to measure streaming potential integral (SPI), after which creep indentation tests were performed. Additionally, degradation level of the tissue was determined in accordance with the International Cartilage Repair Society (ICRS score), and hematoxylin/eosin and safranin O staining were performed to determine the Mankin score. Mechanical test results were evaluated both analytically and by means of a finite-element-optimized parameter identification procedure. The SPI was then correlated with poroelastic E modulus (r=0.563, p < 0.008, n=22), natural logarithm of hydraulic permeability (r=0.374, p < 0.095, n=22) and cartilage degeneration scores (ICRS and Mankin) (r = -0.749, p < 0.000, n=22 and r = -0.409, p < 0.059, n=22 respectively). (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1328 / 1334

页数：7

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