Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

被引：0

作者：

Cardini, Benno ^{[1
]}

Oberhuber, Rupert ^{[1
]}

Hein, Sven R. ^{[1
]}

Watschinger, Katrin ^{[2
]}

Hermann, Martin ^{[3
]}

Obrist, Peter ^{[4
]}

Werner-Felmayer, Gabriele ^{[2
]}

Brandacher, Gerald ^{[5
]}

Pratschke, Johann ^{[1
]}

Werner, Ernst R. ^{[2
]}

Maglione, Manuel ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria

[3] Med Univ Innsbruck, Dept Anesthesiol & Crit Care Med, A-6020 Innsbruck, Austria

[4] St Vinzenz KH, Inst Pathol, Zams, Austria

[5] Johns Hopkins Univ, Sch Med, Comprehens Transplant Ctr, Baltimore, MD USA

来源：

PTERIDINES | 2013年 / 24卷 / 01期

关键词：

animal model; ischemia-reperfusion injury; nitric oxide; organ transplantation; tetrahydrobiopterin; ENDOTHELIUM-DEPENDENT VASODILATION; PANCREAS TRANSPLANTATION; VASCULAR-DISEASE; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; IN-VIVO; DYSFUNCTION; MECHANISMS; ATHEROSCLEROSIS; HYPERCHOLESTEROLEMIA;

D O I：

10.1515/pterid-2013-0006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ischemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin. Suboptimal concentrations of tetrahydrobiopterin result in a reduced biosynthesis of nitric oxide leading to vascular endothelial dysfunction. Tetrahydrobiopterin supplementation has been shown to protect from this pathological state in a plethora of cardiovascular diseases including transplant-related ischemia-reperfusion injury. Even though still controversially discussed, there is increasing evidence emerging from both human as well as animal studies that tetrahydrobiopterin-mediated actions rely on its nitric oxide synthase cofactor activity rather than on its antioxidative properties. Herein, we review the current literature regarding the role of tetrahydrobiopterin in ischemia-reperfusion injury including our experience acquired in a murine pancreas transplantation model.

引用

页码：13 / 19

页数：7

共 73 条

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