HIV-Exposed Uninfected Infants are at Increased Risk for Severe Infections in the First Year of Life

被引：121

作者：

Slogrove, Amy ^{[1
,2
]}

Reikie, Brian ^{[2
,3
]}

Naidoo, Shalena ^{[4
]}

De Beer, Corena ^{[4
]}

Ho, Kevin ^{[2
,3
]}

Cotton, Mark ^{[1
]}

Bettinger, Julie ^{[2
,3
]}

Speert, David ^{[2
,3
]}

Esser, Monika ^{[5
]}

Kollmann, Tobias ^{[2
,3
]}

机构：

[1] Univ Stellenbosch, Dept Paediat & Child Hlth, ZA-7600 Stellenbosch, South Africa

[2] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1W5, Canada

[3] Univ British Columbia, Ctr Understanding & Preventing Infect Children, Div Infect & Immunol Dis, Vancouver, BC V6T 1W5, Canada

[4] Univ Stellenbosch, Natl Hlth Lab Serv, Dept Pathol, ZA-7600 Stellenbosch, South Africa

[5] Tygerberg Childrens Hosp, NHLS Immunol, Cape Town, South Africa

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2012年 / 58卷 / 06期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

HIV-exposed infants; HIV; vertical transmission prevention; PMTCT; South Africa; CHILD-MORTALITY; POOLED ANALYSIS; MORBIDITY; ZIMBABWE; MOTHERS; WOMEN; BORN;

D O I：

10.1093/tropej/fms019

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

HIV-exposed uninfected (HEU) infants have higher infectious morbidity than HIV-unexposed uninfected (HUU) infants. We present the clinical outcomes from a pilot cohort study of 27 HEU and 28 HUU infants. In the absence of infant malnutrition or advanced maternal HIV, HEU infants experienced a 2.74 (0.85-8.78) times greater risk of hospitalization in the first year.

引用

页码：505 / 508

页数：4

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