Prostate specific antigen - A new constituent of breast cyst fluid

被引:42
作者
Diamandis, EP
Yu, H
LopezOtin, C
机构
[1] MT SINAI HOSP, DEPT CLIN BIOCHEM, TORONTO, ON M5G 1X5, CANADA
[2] UNIV TORONTO, DEPT CLIN BIOCHEM, TORONTO, ON M5G 1L5, CANADA
[3] UNIV OVIEDO, FAC MED, DEPT BIOL FUNC, E-33006 OVIEDO, SPAIN
关键词
prostate specific antigen; breast cyst fluid; gross breast cystic disease; breast cancer; prognostic markers;
D O I
10.1007/BF01806144
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We demonstrate for the first time that prostate specific antigen (PSA) is a component of breast cyst fluid. At the cutoff level of 0.01 or 0.03 mu g/L of PSA, 64% or 43% of cyst fluids are positive for PSA, respectively. PSA in cyst fluid, as characterized by high performance liquid chromatography, exists in almost equal concentrations as free PSA, with a molecular weight of 33 KDa, and as PSA bound to alpha(1)-antichymotrypsin, with a molecular weight of 100 KDa. PSA presence was also characterized in cyst fluid by Western blot analysis. These data suggest that PSA is a frequent component of breast cyst fluid. More studies are needed to establish the role of this serine protease in normal breast, gross breast cystic disease, and breast cancer.
引用
收藏
页码:259 / 264
页数:6
相关论文
共 34 条
[1]  
[Anonymous], DIS BREAST
[2]   APOLIPOPROTEIN-D IS THE MAJOR PROTEIN-COMPONENT IN CYST FLUID FROM WOMEN WITH HUMAN BREAST GROSS CYSTIC-DISEASE [J].
BALBIN, M ;
FREIJE, JMP ;
FUEYO, A ;
SANCHEZ, LM ;
LOPEZOTIN, C .
BIOCHEMICAL JOURNAL, 1990, 271 (03) :803-807
[3]  
BALBIN M, 1991, CLIN CHEM, V37, P547
[4]   LEVELS OF 18 NONCONJUGATED AND CONJUGATED STEROIDS IN HUMAN BREAST CYST FLUID - RELATIONSHIPS WITH CYST TYPE [J].
BELANGER, A ;
CARON, S ;
LABRIE, F ;
NALDONI, C ;
DOGLIOTTI, L ;
ANGELI, A .
EUROPEAN JOURNAL OF CANCER, 1990, 26 (03) :277-281
[5]  
BOCCARDO F, 1988, CANCER RES, V48, P5860
[6]   RELATIONSHIP OF BENIGN BREAST DISEASE TO BREAST-CANCER [J].
BRINTON, LA .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 586 :266-271
[7]   RISK OF BREAST-CANCER SUBSEQUENT TO PROVEN GROSS CYSTIC-DISEASE [J].
CIATTO, S ;
BIGGERI, A ;
DELTURCO, MR ;
BARTOLI, D ;
IOSSA, A .
EUROPEAN JOURNAL OF CANCER, 1990, 26 (05) :555-557
[8]   GLANDULAR KALLIKREINS AND PROSTATE-SPECIFIC ANTIGEN ARE EXPRESSED IN THE HUMAN ENDOMETRIUM [J].
CLEMENTS, J ;
MUKHTAR, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (06) :1536-1539
[9]   DETECTION OF PROSTATE-SPECIFIC ANTIGEN IMMUNOREACTIVITY IN BREAST TURNERS [J].
DIAMANDIS, EP ;
YU, H ;
SUTHERLAND, DJA .
BREAST CANCER RESEARCH AND TREATMENT, 1994, 32 (03) :301-310
[10]   NEW BIOLOGICAL FUNCTIONS OF PROSTATE-SPECIFIC ANTIGEN [J].
DIAMANDIS, EP ;
YU, H .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (05) :1515-1517