Treponema pallidum outer membrane proteins: current status and prospects

被引：9

作者：

Chen, Jinlin ^{[1
]}

Huang, Jielite ^{[1
]}

Liu, Zhuoran ^{[1
]}

Xie, Yafeng ^{[1
]}

机构：

[1] Univ South China, Dept Clin Lab, Affiliated Hosp 2, Hengyang 421001, Peoples R China

来源：

PATHOGENS AND DISEASE | 2022年 / 80卷 / 01期

关键词：

Treponema pallidum; diagnosis; vaccine; pathogenesis; SEROLOGICAL DIAGNOSIS; CHITOSAN NANOPARTICLES; PROTECTIVE EFFICACY; ANTIGENIC VARIATION; IMMUNE-RESPONSES; LIPOPROTEIN; SYPHILIS; SURFACE; BINDING; TP92;

D O I：

10.1093/femspd/ftac023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The outer membrane proteins (OMPs) of Treponema pallidum subsp. pallidum (T. pallidum), the etiological agent of the sexually transmitted disease syphilis, have long been a hot research topic. Despite many hurdles to studying the pathogen, especially the inability to manipulate T. pallidum in vitro genetically, considerable progress has been made in elucidating the structure, pathogenesis and functions of T. pallidum OMPs. In this review, we integrate this information to garner fresh insights into the role of OMPs in the diagnosis, pathogenicity and vaccine development of T. pallidum. Collectively, the essential scientific discussions herein should provide a framework for understanding the current status and prospects of T. pallidum OMPs. This review summarizes information about selected outer membrane proteins of Treponema pallidum and highlights their possible use as part of a vaccine cocktail.

引用

页数：7

共 67 条

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