Analgesic sesquiterpene dilactone from Mikania cordata

被引：17

作者：

Ahmed, M ^{[1
]}

Rahman, MT ^{[1
]}

Alimuzzaman, M ^{[1
]}

Shilpi, JA ^{[1
]}

机构：

[1] Univ Dhaka, Dept Pharm, Dhaka 1000, Bangladesh

来源：

FITOTERAPIA | 2001年 / 72卷 / 08期

关键词：

Mikania cordata; sesquiterpene dilactones; analgesic activity;

D O I：

10.1016/S0367-326X(01)00318-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydro-mikanolide and scandenolide, did not show significant analgesic activity. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：919 / 921

页数：3

相关论文

共 15 条

[1] GERMACRANOLIDES OF MIKANIA-CORDATA [J].

AGUINALDO, AM ;

ABE, F ;

YAMAUCHI, T ;

PADOLINA, WG .

PHYTOCHEMISTRY, 1995, 38 (06) :1441-1443

[2]

AHMED M, 1990, PHARMAZIE, V45, P697

[3]

[Anonymous], [No title captured]

[4] PROTECTIVE EFFECTS OF MIKANIA-CORDATA ROOT EXTRACT AGAINST PHYSICAL AND CHEMICAL FACTORS-INDUCED GASTRIC-EROSIONS IN EXPERIMENTAL-ANIMALS [J].

BISHAYEE, A ;

CHATTERJEE, M .

PLANTA MEDICA, 1994, 60 (02) :110-113

[5] ANTICARCINOGENIC BIOLOGICAL RESPONSE OF MIKANIA-CORDATA - REFLECTIONS IN HEPATIC BIOTRANSFORMATION SYSTEMS [J].

BISHAYEE, A ;

CHATTERJEE, M .

CANCER LETTERS, 1994, 81 (02) :193-200

[6] NEW DITERPENES AND GERMACRANOLIDES FROM MIKANIA SPECIES [J].

BOHLMANN, F ;

NATU, AA ;

MAHANTA, PK .

PHYTOCHEMISTRY, 1978, 17 (03) :483-485

[7] STRUCTURE ELUCIDATION OF SESQUITERPENE DILACTONES FROM MIKANIA-SCANDENS (L) WILLD [J].

HERZ, W ;

SUBRAMANIAM, PS ;

SANTHANAM, PS ;

AOTA, K ;

HALL, AL .

JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (05) :1453-+

[8] THE GERMACRADIENOLIDE ISABELIN FROM ZEXMENIA-VALERII - STEREOCHEMISTRY AND CONFORMATION OF SCANDENOLIDE AND DEOXYMIKANOLIDE [J].

HERZ, W ;

GOVINDAN, SV .

PHYTOCHEMISTRY, 1981, 20 (07) :1740-1742

[9] CONSTITUENTS OF MIKANIA CORDATA (BURM F.) ROBINSON,BL (COMPOSITAE) .2. [J].

KIANG, AK ;

SIM, KY ;

YOONG, SW .

PHYTOCHEMISTRY, 1968, 7 (06) :1035-&

[10]

MANDAL PK, 1992, ITAL J BIOCHEM, V41, P345