Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

被引：28

作者：

Cellini, Francesco ^{[1
]}

Arcelli, Alessandra ^{[2
]}

Simoni, Nicola ^{[3
]}

Caravatta, Luciana ^{[4
]}

Buwenge, Milly ^{[2
]}

Calabrese, Angela ^{[5
]}

Brunetti, Oronzo ^{[6
]}

Genovesi, Domenico ^{[4
,7
]}

Mazzarotto, Renzo ^{[3
]}

Deodato, Francesco ^{[8
,9
]}

Mattiucci, Gian Carlo ^{[1
,8
]}

Silvestris, Nicola ^{[10
,11
]}

Valentini, Vincenzo ^{[1
,8
]}

Morganti, Alessio Giuseppe ^{[2
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, UOC Radioterapia Oncol, Dipartimento Diagnost Immagini Radioterapia Oncol, I-00168 Rome, Italy

[2] Univ Bologna, S Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med DIMES, Radiat Oncol Ctr, I-40138 Bologna, Italy

[3] Azienda Osped Univ, Radiotherapy Unit, I-37126 Verona, Italy

[4] G DAnnunzio Univ Via Dei Vestini, SS Annunziata Hosp, Dept Radiat Oncol, I-66100 Chieti, Italy

[5] IRCCS Ist Tumori Giovanni Paolo II Bari, Radiol Unit, I-70124 Bari, Italy

[6] IRCCS Ist Tumori Giovanni Paolo II, Med Oncol Unit, Viale Orazio Flacco 65, I-70124 Bari, Italy

[7] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, I-66100 Chieti, Italy

[8] Univ Cattolica Sacro Cuore, Ist Radiol, I-00168 Rome, Italy

[9] Gemelli Molise Hosp, Radiotherapy Unit, I-86100 Campobasso, Italy

[10] IRCCS Ist Tumori Giovanni Paolo II Bari, I-70124 Bari, Italy

[11] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

来源：

CANCERS | 2020年 / 12卷 / 07期

关键词：

pancreatic cancer; radiotherapy; immunotherapy; SBRT; guidelines; review; CTV; MR guided RT; protons; SIB; STEREOTACTIC BODY RADIOTHERAPY; GEMCITABINE PLUS RADIOTHERAPY; GROSS TUMOR VOLUME; PHASE-III TRIAL; DOSE-ESCALATION; NEOADJUVANT CHEMORADIATION; DUCTAL ADENOCARCINOMA; CURATIVE RESECTION; AMERICAN SOCIETY; FOLLOW-UP;

D O I：

10.3390/cancers12071729

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation's definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy.

引用

页码：1 / 41

页数：40

共 164 条

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