Ultra-adaptable nanovesicular systems: a carrier for systemic delivery of therapeutic agents

被引：91

作者：

Kumar, Ajay ^{[1
]}

Pathak, Kamla ^{[1
]}

Bali, Vikas ^{[1
]}

机构：

[1] Rajiv Acad Pharm, Dept Pharmaceut, Mathura 281001, Uttar Pradesh, India

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 21-22期

关键词：

ULTRADEFORMABLE DRUG CARRIERS; TRANSDERMAL DELIVERY; DEFORMABLE VESICLES; SKIN PERMEATION; TRANSFERSOMES; LIPOSOMES; VACCINE; ENHANCEMENT; PENETRATION; FORMULATION;

D O I：

10.1016/j.drudis.2012.06.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The skin acts as a barrier and prevents trans cutaneous delivery of therapeutic agents. Transferosomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of phospholipids, edge activator and ethanol and are applied in a non-occlusive manner. Owing to their ultradeformability, they have the potential to deliver therapeutic agents across the intact skin in a non-invasive and non-allergenic manner. The present review attempts to provide an in-depth account of ultra-adaptable nanovesicular systems. The current investigation, besides compiling existing knowledge in a systematic manner, also includes information like regulatory aspects of excipients used in preparation, summary of clinical investigations performed, marketed preparations available, research reports and patent reports related to transfersomes.

引用

页码：1233 / 1241

页数：9

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