PVC supported liquid membrane and carbon paste potentiometric sensors incorporating a Mn(III)-porphyrin for the direct determination of undissociated paracetamol

被引:14
作者
Saraswathyamma, Beena [2 ]
Pajak, Marta [1 ]
Radecki, Jerzy [1 ]
Maes, Wouter [3 ]
Dehaen, Wim [3 ]
Kumar, Krishnapillai Girish [2 ]
Radecka, Hanna [1 ]
机构
[1] Polish Acad Sci, Inst Anim Reprod & Food Res, PL-10747 Olsztyn, Poland
[2] Cochin Univ Sci & Technol, Dept Appl Chem, Cochin 682022, Kerala, India
[3] Univ Louvain, Dept Chem, B-3001 Louvain, Belgium
关键词
Mn(III)-porphyrin; ISE; carbon paste; neutral guest; paracetamol;
D O I
10.1002/elan.200804280
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
PVC supported liquid membrane and carbon paste potentiometric sensors incorporating an Mn(III)-porphyrin complex as a neutral host molecule were developed for the determination of paracetamol. The measurements were carried out in solution at pH 5.5. Under such conditions paracetamol exists as a neutral molecule. The mechanism of molecular recognition between the Mn(Ill)-porphyrin and paracetamol, leading to potentiometric signal generation is discussed. The sensitivity and selectivity toward paracetamol of carbon paste and polymeric liquid membrane electrodes incorporating an Mn(III)-porphyrin host were compared. The applicability of these sensors to the direct determination of paracetamol was checked by performing a recovery test in human plasma.
引用
收藏
页码:2009 / 2015
页数:7
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