2,4,6-Trichloro-1,3,5-triazine (TCT) mediated one pot direct synthesis of N-benzoylthioureas from carboxylic acids

被引：17

作者：

Gholap, Somnath ^{[1
]}

Gunjal, Navanath ^{[1
]}

机构：

[1] Padmashri Vikhe Patil Coll, Dept Chem, Pravaranagar Tal Rahata 413713, MS, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2017年 / 10卷

关键词：

Trichloro-triazine (TCT); Carboxylic acid; Amines; N-Benzoylthiourea; Aroylthiocyanate; One-pot method; PHASE-TRANSFER CATALYSIS; CYANURIC CHLORIDE; BIOLOGICAL EVALUATION; DERIVATIVES; REAGENT; MILD; ISOTHIOCYANATES; AGENTS;

D O I：

10.1016/j.arabjc.2013.10.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient 2,4,6-trichloro-1,3,5-triazine (TCT) mediated synthesis of N-benzoylthiourea derivatives from carboxylic acid has been described. The reaction of TCT (1), triethyl amine in dichloromethane gives tris-quaternary ammonium salt (A), reacted with carboxylic acid to form activated ester as an intermediate (B). Aroylthiocyanate was formed by the reaction of activated ester 'B' and ammonium isothiocyanate followed by aliphatic or aromatic amines affording structurally diverse N-benzoylthiourea derivatives 3. The synthesized compounds were characterized by IR, H-1 NMR and mass spectral data. (C) 2013 King Saud University. Production and hosting by Elsevier B.V.

引用

页码：S2750 / S2753

页数：4

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