Neuroprotective role of erythropoietin in neonates

被引：39
作者：
Juul, Sandra [1 ]
机构：
[1] Univ Washington, Div Neonatol, Dept Paediat, Seattle, WA 98195 USA
来源：
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷
关键词：
Erythropoietin; neuroprotection; neonates; DOSE RECOMBINANT ERYTHROPOIETIN; BIRTH-WEIGHT INFANTS; BRAIN-INJURY; PRETERM INFANTS; HYPOXIA/ISCHEMIA; RATS; PHARMACOKINETICS; TRIAL;
D O I：
10.3109/14767058.2012.715025
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This review summarizes target populations of neonates for which erythropoietin (Epo) neuroprotective therapy might be of benefit, and the mechanisms by which Epo functions as a neuroprotective agent. Potential risks of Epo are reviewed. Finally, the progression of Epo neuroprotection from preclinical studies to translational studies is discussed.
引用
收藏
页码：105 / 107
页数：3
相关论文
共 22 条
[1]   National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications [J].
Blencowe, Hannah ;
Cousens, Simon ;
Oestergaard, Mikkel Z. ;
Chou, Doris ;
Moller, Ann-Beth ;
Narwal, Rajesh ;
Adler, Alma ;
Garcia, Claudia Vera ;
Rohde, Sarah ;
Say, Lale ;
Lawn, Joy E. .
LANCET, 2012, 379 (9832) :2162-2172
[2]   An association between infantile haemangiomas and erythropoietin treatment in preterm infants [J].
Doege, Corinna ;
Pritsch, Maria ;
Fruehwald, Michael C. ;
Bauer, Jacqueline .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2012, 97 (01) :F45-F49
[3]   Human Recombinant Erythropoietin in Asphyxia Neonatorum: Pilot Trial [J].
Elmahdy, Heba ;
El-Mashad, Abdel-Rahman ;
El-Bahrawy, Hoda ;
El-Gohary, Tareq ;
El-Barbary, Ali ;
Aly, Hany .
PEDIATRICS, 2010, 125 (05) :E1135-E1142
[4]   An approach to using recombinant erythropoietin for neuroprotection in very preterm infants [J].
Fauchere, Jean-Claude ;
Dame, Christof ;
Vonthein, Reinhard ;
Koller, Brigitte ;
Arri, Sandra ;
Wolf, Martin ;
Bucher, Hans Ulrich .
PEDIATRICS, 2008, 122 (02) :375-382
[5]   Systemic Inflammation Disrupts the Developmental Program of White Matter [J].
Favrais, Geraldine ;
van de Looij, Yohan ;
Fleiss, Bobbi ;
Ramanantsoa, Nelina ;
Bonnin, Philippe ;
Stoltenburg-Didinger, Gisela ;
Lacaud, Adrien ;
Saliba, Elie ;
Dammann, Olaf ;
Gallego, Jorge ;
Sizonenko, Stephane ;
Hagberg, Henrik ;
Lelievre, Vincent ;
Gressens, Pierre .
ANNALS OF NEUROLOGY, 2011, 70 (04) :550-565
[6]   Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats [J].
Iwai, Masanori ;
Cao, Guodong ;
Yin, Wei ;
Stetler, R. Anne ;
Liu, Jialing ;
Chen, Jun .
STROKE, 2007, 38 (10) :2795-2803
[7]   Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury [J].
Iwai, Masanori ;
Stetler, R. Anne ;
Xing, Juan ;
Hu, Xiaoming ;
Gao, Yanqin ;
Zhang, Wenting ;
Chen, Jun ;
Cao, Guodong .
STROKE, 2010, 41 (05) :1032-1037
[8]   Epo and other hematopoietic factors [J].
Juul, Sandra ;
Felderhoff-Mueser, Ursula .
SEMINARS IN FETAL & NEONATAL MEDICINE, 2007, 12 (04) :250-258
[9]   A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: Pharmacokinetics and safety [J].
Juul, Sandra E. ;
McPherson, Ronald J. ;
Bauer, Larry A. ;
Ledbetter, Kelly J. ;
Gleason, Christine A. ;
Mayock, Dennis E. .
PEDIATRICS, 2008, 122 (02) :383-391
[10]   Microarray Analysis of High-Dose Recombinant Erythropoietin Treatment of Unilateral Brain Injury in Neonatal Mouse Hippocampus [J].
Juul, Sandra E. ;
Beyer, Richard P. ;
Bammler, Theo K. ;
Mcpherson, Ronald J. ;
Wilkerson, Jasmine ;
Farin, Federico M. .
PEDIATRIC RESEARCH, 2009, 65 (05) :485-492
123