Genetic predisposition and hematopoietic malignancies in children: Primary immunodeficiency

被引：16

作者：

ten Bosch, Jutte van der Werff ^{[1
]}

van den Akker, Machiel ^{[1
,2
]}

机构：

[1] Univ Ziekenhuis Brussel, Brussels, Belgium

[2] Paola Kinderziekenhuis Antwerpen, Antwerp, Belgium

来源：

European Journal of Medical Genetics | 2016年 / 59卷 / 12期

关键词：

Primary immuno deficiency; Leukemia; Lymphoma; Children; SEVERE CONGENITAL NEUTROPENIA; HYPER-IGE SYNDROME; ACUTE MYELOID-LEUKEMIA; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; ACUTE LYMPHOBLASTIC-LEUKEMIA; X-LINKED AGAMMAGLOBULINEMIA; CARTILAGE-HAIR HYPOPLASIA; EPSTEIN-BARR-VIRUS; COMMON VARIABLE IMMUNODEFICIENCY; WISKOTT-ALDRICH SYNDROME;

D O I：

10.1016/j.ejmg.2016.03.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is assumed that patients with some forms of primary immunodeficiency (PID) have a markedly increased risk of cancer as compared to the healthy population. This increased incidence is seen in children as well as adult patients. The type of malignancy depends on the underlying genetic defect, but hematopoietic cancers are most frequent in almost any subtype of PID. In some patients, a malignancy can even be the first or only symptom of an underlying genetic defect. The possibility of an underlying PID is important for the pediatric oncologist as this might influence the treatment. Also, patients with a known PID should be screened for the occurrence of cancer. It is therefore important to raise awareness on this subject among clinicians involved in the treatment of children with cancer as well as in the treatment of children with PID. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：647 / 653

页数：7

相关论文

共 104 条

[1] Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia [J].

Abu-Arja, Rolla F. ;

Chernin, Leah R. ;

Abusin, Ghada ;

Auletta, Jeffery ;

Cabral, Linda ;

Egler, Rachel ;

Ochs, Hans D. ;

Torgerson, Troy R. ;

Lopez-Guisa, Jesus ;

Hostoffer, Robert W. ;

Tcheurekdjian, Haig ;

Cooke, Kenneth R. .

PEDIATRIC BLOOD & CANCER, 2015, 62 (09) :1674-1676

[2] Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia [J].

Beekman, Renee ;

Valkhof, Marijke G. ;

Sanders, Mathijs A. ;

van Strien, Paulette M. H. ;

Haanstra, Jurgen R. ;

Broeders, Lianne ;

Geertsma-Kleinekoort, Wendy M. ;

Veerman, Anjo J. P. ;

Valk, Peter J. M. ;

Verhaak, Roel G. ;

Lowenberg, Bob ;

Touw, Ivo P. .

BLOOD, 2012, 119 (22) :5071-5077

[3]

Beltinger C, 1998, BLOOD, V91, P3943

[4] The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency [J].

Bigley, Venetia ;

Haniffa, Muzlifah ;

Doulatov, Sergei ;

Wang, Xiao-Nong ;

Dickinson, Rachel ;

McGovern, Naomi ;

Jardine, Laura ;

Pagan, Sarah ;

Dimmick, Ian ;

Chua, Ignatius ;

Wallis, Jonathan ;

Lordan, Jim ;

Morgan, Cliff ;

Kumararatne, Dinakantha S. ;

Doffinger, Rainer ;

van der Burg, Mirjam ;

van Dongen, Jacques ;

Cant, Andrew ;

Dick, John E. ;

Hambleton, Sophie ;

Collin, Matthew .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :227-234

[5] SEVERE HERPESVIRUS INFECTIONS IN AN ADOLESCENT WITHOUT NATURAL-KILLER CELLS [J].

BIRON, CA ;

BYRON, KS ;

SULLIVAN, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (26) :1731-1735

[6] Primary Immunodeficiency Diseases Worldwide: More Common than Generally Thought [J].

Bousfiha, Ahmed Aziz ;

Jeddane, Leila ;

Ailal, Fatima ;

Benhsaien, Ibtihal ;

Mahlaoui, Nizar ;

Casanova, Jean-Laurent ;

Abel, Laurent .

JOURNAL OF CLINICAL IMMUNOLOGY, 2013, 33 (01) :1-7

[7] Population prevalence of diagnosed primary immunodeficiency diseases in the United States [J].

Boyle, J. M. ;

Buckley, R. H. .

JOURNAL OF CLINICAL IMMUNOLOGY, 2007, 27 (05) :497-502

[8] Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP) [J].

Brandau, O ;

Schuster, V ;

Weiss, M ;

Hellebrand, H ;

Fink, FM ;

Kreczy, A ;

Friedrich, W ;

Strahm, B ;

Niemeyer, C ;

Belohradsky, BH ;

Meindl, A .

HUMAN MOLECULAR GENETICS, 1999, 8 (13) :2407-2413

[9] W iskott-Aldrich syndrome: diagnosis, current management, and emerging treatments [J].

Buchbinder, David ;

Nugent, Diane J. ;

Fillipovich, Alexandra H. .

APPLICATION OF CLINICAL GENETICS, 2014, 7 :55-66

[10] Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly [J].

Buck, D ;

Malivert, L ;

de Chasseval, P ;

Barraud, A ;

Fondanèche, MC ;

Sanal, O ;

Plebani, A ;

Stéphan, JL ;

Hufnagel, M ;

le Deist, F ;

Fischer, A ;

Durandy, A ;

de Villartay, JP ;

Revy, P .

CELL, 2006, 124 (02) :287-299

← 1 2 3 4 5 6 7 8 9 10 →