Prostaglandins in asthma and allergic diseases

被引:77
作者
Peebles, R. Stokes, Jr. [1 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Allergy Pulm & Crit Care Med, Nashville, TN 37232 USA
基金
美国国家卫生研究院;
关键词
Prostaglandin; Cyclooxygenase; Lung; Allergy; Asthma; RECEPTOR-HOMOLOGOUS MOLECULE; AIRWAY SMOOTH-MUSCLE; E-PROSTANOID; EXERCISE-INDUCED BRONCHOCONSTRICTION; EXACERBATED RESPIRATORY-DISEASE; INFLAMMATORY MEDIATOR RELEASE; CRTH2 ANTAGONIST OC000459; EXHALED NITRIC-OXIDE; HELPER TYPE-2 CELLS; THROMBOXANE A(2);
D O I
10.1016/j.pharmthera.2018.08.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Prostaglandins are synthesized through the metabolism of arachidonic acid via the cyclooxygenase pathway. There are five primary prostaglandins, PGD(2), PGE(2,) PGF(2), PGI(2), and thromboxane B-2, that all signal through distinct seven transmembrane, G-protein coupled receptors. The receptors through which the prostaglandins signal determines their immunologic or physiologic effects. For instance, the same prostaglandin may have opposing properties, dependent upon the signaling pathways activated. In this article, we will detail how inhibition of cyclooxygenase metabolism and regulation of prostaglandin signaling regulates allergic airway inflammation and asthma physiology. Possible prostaglandin therapeutic targets for allergic lung inflammation and asthma will also be reviewed, as informed by human studies, basic science, and animal models. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:1 / 19
页数:19
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