Balancing the risk and benefits of low-dose aspirin in clinical practice

被引：14

作者：

Casado-Arroyo, Ruben ^{[1
,3
]}

Gargallo, Carla ^{[2
]}

Arbeloa, Angel Lanas ^{[2
,3
]}

机构：

[1] Free Univ Brussels UZ Brussel VUB, Ctr Cardiovasc, Heart Rhythm Management Ctr, B-1090 Brussels, Belgium

[2] Univ Hosp Lozano Blesa, Serv Digest Dis, Zaragoza, Spain

[3] Aragon Hlth Sci Inst, CIBERehd, Zaragoza, Spain

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2012年 / 26卷 / 02期

关键词：

Aspirin; Prevention cardiovascular diseases; GI damage; Proton pump inhibitors; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HELICOBACTER-PYLORI INFECTION; EXPERT CONSENSUS DOCUMENT; FOUNDATION TASK-FORCE; ACETYLSALICYLIC-ACID; COLORECTAL-CANCER; GASTROINTESTINAL RISKS; CARDIOVASCULAR-DISEASE; ANTIPLATELET THERAPY; RANDOMIZED-TRIAL;

D O I：

10.1016/j.bpg.2012.01.015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Antiplatelet agents are widely used in primary and secondary prevention of cardiovascular events. The scientific evidence has provided strong support for the benefits of aspirin in decreasing the risk of cardiovascular events in a wide range of pathologies. The relatively rare occurrence of major bleeding complications should not be underestimated, mainly due to its high morbimortality. The assessment of both gastrointestinal risk and cardiovascular benefits of low-dose aspirin for any individual patient may be difficult in clinical practice. In this review, we summarize the evidence supporting the efficacy of aspirin and the risks of side effects due to hemorrhagic complications. This article proposes a unifying framework for application to help the clinician in the decision making process of individuals who have different risk of cardiovascular and bleeding events with different examples. Finally, new developments in the field directed towards individualized risk assessment strategies are described. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：173 / 184

页数：12

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