Non-coding RNAs and gastric cancer

被引：140
作者：
Li, Pei-Fei [1 ]
Chen, Sheng-Can [1 ]
Xia, Tian [1 ]
Jiang, Xiao-Ming [1 ]
Shao, Yong-Fu [1 ]
Xiao, Bing-Xiu [1 ]
Guo, Jun-Ming [1 ]
机构：
[1] Ningbo Univ, Zhejiang Prov Key Lab Pathophysiol, Sch Med, Dept Biochem & Mol Biol, Ningbo 315211, Zhejiang, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 18期
基金：
中国国家自然科学基金;
关键词：
Non-coding RNA; MicroRNA; Piwi-interacting RNA; Long non-coding RNA; Small interfering RNA; Gastric cancer; PIWI-INTERACTING RNAS; SMALL INTERFERING RNA; EPIGENETIC REGULATION; CELL-PROLIFERATION; BRAIN-DEVELOPMENT; C-MYC; EXPRESSION; MICRORNAS; TRANSCRIPTION; CARCINOMA;
D O I：
10.3748/wjg.v20.i18.5411
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Non-coding RNAs (ncRNAs) play key roles in development, proliferation, differentiation and apoptosis. Altered ncRNA expression is associated with gastric cancer occurrence, invasion, and metastasis. Moreover, aberrant expression of microRNAs (miRNAs) is significantly related to gastric cancer tumor stage, size, differentiation and metastasis. MiRNAs interrupt cellular signaling pathways, inhibit the activity of tumor suppressor genes, and affect the cell cycle in gastric cancer cells. Some miRNAs, including miR-21, miR-106a and miR-421, could be potential markers for the diagnosis of gastric cancer. Long non-coding RNAs (IncRNAs), a new research hotspot among cancer-associated ncRNAs, play important roles in epigenetic, transcriptional and post-transcriptional regulation. Several gastric cancer-associated IncRNAs, such as CCAT1, GACAT1, H19, and SUMO1P3, have been explored. In addition, Piwi-interacting RNAs, another type of small ncRNA that is recognized by gastroenterologists, are involved in gastric carcinogenesis, and piR-651/823 represents an efficient diagnostic biomarker of gastric cancer that can be detected in the blood and gastric juice. Small interfering RNAs also function in post-transcriptional regulation in gastric cancer and might be useful in gastric cancer treatment. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
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收藏
页码：5411 / 5419
页数：9
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