Prevention of Recurrent Staphylococcal Skin Infections

被引:70
作者
Creech, C. Buddy [1 ,2 ]
Al-Zubeidi, Duha N. [3 ]
Fritz, Stephanie A. [4 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Pediat, Vanderbilt Vaccine Res Program,Div Pediat Infect, Nashville, TN 37232 USA
[2] Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN 37232 USA
[3] Univ Missouri, Sch Med, Childrens Mercy Hosp Infect Prevent & Control, Dept Pediat, Kansas City, MO 64108 USA
[4] Washington Univ, Sch Med, Dept Pediat, Div Pediat Infect Dis, St Louis, MO 63110 USA
基金
美国国家卫生研究院; 美国医疗保健研究与质量局;
关键词
Staphylococcus aureus; MRSA; Skin infection; Prevention; Decolonization; Staphylococcal vaccine; Pediatrics; ACQUIRED METHICILLIN-RESISTANT; SOFT-TISSUE INFECTIONS; RANDOMIZED CONTROLLED-TRIAL; AUREUS NASAL COLONIZATION; BACTERIAL INTERFERENCE; INTRANASAL MUPIROCIN; ENVIRONMENTAL CONTAMINATION; DOUBLE-BLIND; RISK-FACTORS; CHLORHEXIDINE RESISTANCE;
D O I
10.1016/j.idc.2015.05.007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Staphylococcus aureus infections pose a significant health burden. The emergence of community-associated methicillin-resistant S aureus has resulted in an epidemic of skin and soft tissue infections (SSTI), and many patients experience recurrent SSTI. As S aureus colonization is associated with subsequent infection, decolonization is recommended for patients with recurrent SSTI or in settings of ongoing transmission. S aureus infections often cluster within households, and asymptomatic carriers serve as reservoirs for transmission; therefore, a household approach to decolonization is more effective than measures performed by individuals alone. Novel strategies for the prevention of recurrent SSTI are needed.
引用
收藏
页码:429 / +
页数:37
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