Dimerization of substituted 2-aminobenzoic acids under Vilsmeier conditions: A novel route to the synthesis of 4-(3H)-quinazolinones.

被引：53

作者：

Majo, VJ ^{[1
]}

Perumal, PT ^{[1
]}

机构：

[1] CENT LEATHER RES INST,DIV ORGAN CHEM,MADRAS 600020,TAMIL NADU,INDIA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 28期

关键词：

D O I：

10.1016/0040-4039(96)01022-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various substituted 2-aminobenzoic acids on treatment with Vilsmeier reagent (DMF/POCl3) at 80-90 degrees C undergo a novel dimerization reaction to yield 2-[3,4-dihydro-4-oxo-3-quinazolinoyl]-N,N-dimethyl benzamides. The interruption of dimerization at rt by the addition of primary amines affords the corresponding quinazolinones. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5015 / 5018

页数：4

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